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Zarnestra

See product T108 Tipifarnib

Prices
  • 5 mg - 103 EUR
  • 25 mg - 412 EUR
  • 100 mg - 1236 EUR

ZM447439

ZM447439 was the first inhibitor of the Aurora kinase family to be developed and characterized. It has IC50 values of 50 nM, 1 microM and 250 nM for Aurora kinases B, A and C, respectively. Its inhibition of these kinases interferes with the mitotic spindle integrity checkpoint and chromosome segregation.

catalogue number: Z082
synonyms:
CAS: 331771-20-1
MW: 513.59 g/mol

References
Mol Biol Cell. 2005 Mar;16(3):1305-18. PMID: 15616188
Biochem Pharmacol. 2010 Jan 15;79(2):122-9. PMID: 19686703

Prices
  • 25 mg - 60 EUR
  • 100 mg - 180 EUR
  • 250 mg - 360 EUR

ZSTK474

ZSTK474 is a new PI3K inhibitor with strong antitumor activity against human cancer xenografts without toxic effects in critical organs. Biochemical experiments confirmed ZSTK474 to be a potent pan-class I PI3K inhibitor (Ki values for alpha, beta, gamma, delta isoforms are 6.7 nM, 10.4 nM, 11.7 nM, and 1.8, nM respectively), with high selectivity over other classes of PI3K and protein kinases.

catalogue number: Z143
synonyms:
CAS: 475110-96-4
MW: 417.41 g/mol

References
J Natl Cancer Inst. 2006 Apr 19;98(8):545-56. PMID: 16622124
Acta Pharmacol Sin. 2010 Sep;31(9):1189-97. PMID: 20729870