Alphabetical listing of all products

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Prices
  • 5 mg - 176 EUR
  • 25 mg - 704 EUR
  • 100 mg - 2112 EUR

Neratinib

Neratinib is an orally available tyrosine kinase inhibitor with IC50 values of 59 nM and 92 nM for HER2 and EGFR, respectively. In contrast to other tyrosine kinase inhibitors that are ATP-competitors, Neratinib binds to the HER2 receptor irreversibly, forming a covalent bond with a cysteine residue in the ATP-binding pocket. Treatment of cells with neratinib inhibits mitogenic signal transduction events and induces arrest during the G1/S phase transition of the cell cycle.

catalogue number: N054
synonyms: HKI-272
CAS: 698387-09-6
MW: 557.04 g/mol

References
Cancer Res. 2004 Jun 1;64(11):3958-65. PMID: 15173008
J Med Chem. 2005 Feb 24;48(4):1107-31. PMID: 15715478

Prices
  • 5 mg - 98 EUR
  • 25 mg - 392 EUR
  • 100 mg - 1176 EUR

NG38

NG38 is an estrogen sulfotransferase (EST) inhibitor identified from a trisubstituted purine library. It has an IC50 of 500 nM against the purified enzyme. EST catalyzes the transfer of a sulfuryl group to estrogens in the cytosol, solubilizing them to maintain hormone homeostasis. Unusually high levels of estrogen sulfate are found in breast tumor cells and EST is therefore considered to be a potential drug target. Unusually high levels of estrogen sulfate are found in breast tumor cells and EST is therefore considered as a possible drug target.

catalogue number: N055
synonyms:
CAS: 244030-38-4
MW: 394.51 g/mol

References
J Med Chem. 2001 Aug 16;44(17):2683-6. PMID: 11495578

Prices
  • 25 mg - 103 EUR
  • 100 mg - 309 EUR
  • 250 mg - 618 EUR

Nilotinib

Nilotinib is a potent inhibitor of the BCR/Abl protein kinase that was developed as a drug against Philadelphia chromosome positive chronic myeloid and acute lymphoblastic leukemias. Nilotinib is approximately 20 times more potent than imatinib, and this translates into improved inhibitory activity against most of the common BCR-ABL mutations.

catalogue number: N056
synonyms: AMN-107, Tasigna
CAS: 641571-10-0
MW: 529.52 g/mol

References
Cancer Cell. 2005 Feb;7(2):117-9. PMID: 15710324
Cancer Cell. 2005 Feb;7(2):129-41. PMID: 15710326
Br J Cancer. 2006 Jun 19;94(12):1765-9. PMID: 16721371
Crystal structure of ABL in complex with nilotinib PDB: 3CS9

Prices
  • 5 mg - 140 EUR
  • 25 mg - 560 EUR
  • 100 mg - 1680 EUR

Nutlin-3

Nutlin-3 is an inhibitor of protein-protein interactions between the p53 tumour suppressor and the protooncogene MDM-2. Nutlin-3 binds to MDM-2 in the p53-binding pocket with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutations in p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice.

catalogue number: N095
synonyms:
CAS: 548472-68-0
MW: 581.5 g/mol

References
Science. 2004 Feb 6;303(5659):844-8. PMID: 14704432