Alphabetical listing of all products

A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

Prices
  • 25 mg - 172 EUR
  • 100 mg - 516 EUR
  • 250 mg - 1032 EUR

Masitinib

Masitinib is a tyrosine kinase inhibitor that targets KIT with an IC50 value of 200 nM. Masitinib also potently inhibited recombinant PDGFR and the intracellular kinase Lyn. In contrast, it was a weak inhibitor of ABL and c-Fms and was inactive against a variety of other tyrosine and serine/threonine kinases. Kinetic analyses suggest that its mode of binding is different from that of imatinib; it also proved to be a stronger inhibitor of degranulation, cytokine production, and bone marrow mast cell migration than imatinib. It has been approved as a veterinary medicine for the treatment of mast cell tumors in dogs.

catalogue number: M102
synonyms: AB1010, Masivet, Masatinib
CAS: 790299-79-5
MW: 498.64 g/mol

References
PLoS One. 2009 Sep 30;4(9):e7258. PMID: 19789626

Prices
  • 5 mg - 43 EUR
  • 25 mg - 172 EUR
  • 100 mg - 516 EUR

2-Methoxyestradiol

2-Methoxyestradiol is a steroid-like compound with very weak affinity for estrogen receptors. 2-ME2 prevents the formation of new blood vessels that tumors need for their growth (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers. 2-ME2 binds to microtubules and triggers their disruption, leading to an apoptotic cell death. Preclinical models also suggest that it could also be effective against inflammatory diseases such as rheumatoid arthritis.

catalogue number: M003
synonyms: 2-ME2, 2ME2
CAS: 362-07-2
MW: 302.41 g/mol

References
Steroids. 2010 Oct;75(10):625-31. PMID: 20214913
Mol Pharm. 2010 Dec 6;7(6):2030-9. PMID: 20831190

Prices
  • 25 mg - 28 EUR
  • 100 mg - 85 EUR
  • 250 mg - 170 EUR

6-mercaptopurine

6-mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. However, thiopurine drugs have a relatively narrow therapeutic index and can exhibit life-threatening toxicity, often due to myelosuppression. Mercaptopurine inhibits purine nucleotide synthesis and metabolism, altering the synthesis and functioning of RNA and DNA.

catalogue number: M126
synonyms: Mercaptopurine, Purinethol
CAS: 50-44-2
MW: 152.18 g/mol

References
Eur J Clin Pharmacol. 2008 Aug;64(8):753-67. PMID: 18506437
Aliment Pharmacol Ther. 2006 Sep 1;24(5):715-29. PMID: 16918876

Prices
  • 5 mg - 85 EUR
  • 25 mg - 340 EUR
  • 100 mg - 1020 EUR

MG-132

MG-132 is a specific, potent, reversible and cell-permeable proteasome inhibitor with a Ki value of 4 nM. It reduces the degradation of polyubiquitinylated proteins in mammalian cells by blocking the 26S complex.

catalogue number: M049
synonyms: MG132, N-(benzyloxycarbonyl)leucinylleucinylleucinal
CAS: 133407-82-6
MW: 475.62 g/mol

References
J Biochem. 1996 Mar;119(3):572-6. PMID: 8830056
Anticancer Res. 2001 Nov-Dec;21(6A):3941-7. PMID: 11911275

Prices
  • 5 mg - on request
  • 25 mg - on request
  • 100 mg - on request

Mitomycin C

Mitomicin C is a natural product isolated from Streptomyces caespitosus or Streptomyces lavendulae. It is a potent DNA crosslinker with high efficiency and absolute specificity for the sequence CpG. Its binding to DNA causes DNA damage and induces cell death. It produces oxygen radicals and is preferentially toxic to hypoxic cells.

catalogue number: M127
synonyms: Mitomycin, Mutamycin
CAS: 50-07-7
MW: 334.33 g/mol

References
Chem Biol. 1995 Sep;2(9):575-9. PMID: 9383461

Prices
  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

Ixazomib (MLN-2238)

MLN-2238 is a potent, reversible, and specific inhibitor of the 20S proteasome with an IC50 value of 3.4 nM. It is active in preclinical models of lymphoma and lymphoma that are refractory to bortezomib treatment. In therapeutic applications, it is delivered as a prodrug (MLN-9708), which is orally bioavailable and is rapidly hydrolyzed to yield the bioactive species MLN-2238.

catalogue number: M050
synonyms: Ixazomib, MLN-2238
CAS: 1072833-77-2
MW: 361.03 g/mol

References
Clin Cancer Res. 2011 Aug 15;17(16):5311-21 PMID: 21724551

Prices
  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

MLN8054

MLN8054 is an orally bioavailable, potent and selective inhibitor of the protein kinase Aurora A. MLN8054 inhibits AURKA activity with an IC50 of 4 nM (its IC50 for AURKB is 170 nM). MLN8054 treatment results in G2/M cell cycle arrest, spindle defects and cell death in many tumor cell lines.

catalogue number: M051
synonyms:
CAS: 869363-13-3
MW: 476.85 g/mol

References
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. PMID: 17360485
Mol Cell Biol. 2007 Jun;27(12):4513-25. PMID: 17438137

Prices
  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

Motesanib

Motesanib is an oral multikinase inhibitor that selectively targets the vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

catalogue number: M052
synonyms: AMG 706
CAS: 857876-30-3
MW: 569.44 g/mol (diphosphate)

References
Cancer Res. 2006 Sep 1;66(17):8715-21. PMID: 16951187
Crystal structure of the VEGFR2 in complex with motesanib PDB: 3EFL

Prices
  • 5 mg - 98 EUR
  • 25 mg - 392 EUR
  • 100 mg - 1176 EUR

Myoseverin

Myoseverin is a 2,6,9-trisubstituted purine derivative that binds to tubulin and prevents its polymerization. It was discovered in a morphological differentiation screen and induces the reversible fission of multinucleated myotubes into mononucleated fragments. In cancer cells, myoseverin leads to mitotic arrest with subsequent cell death.

catalogue number: M053
synonyms:
CAS: 267402-71-1
MW: 432.52 g/mol

References
Nat Biotechnol. 2000 Mar;18(3):304-8. PMID: 10700146
J Med Chem. 2001 Dec 20;44(26):4497-500. PMID: 11741468
Eur J Med Chem. 2006 Dec;41(12):1405-11. PMID: 16996651