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Prices
  • 5 mg - 208 EUR
  • 25 mg - 832 EUR
  • 100 mg - 2496 EUR

K252a

K252a is an alkaloid related to staurosporin, but isolated from Nocardiopisis sp. soil fungi. It is potent inhibitor of multiple serine/threonine protein kinases (IC50s of 10 to 30 nM), including Ca2+/calmodulin-dependent protein kinase II, protein kinase A, protein kinase C and protein kinase G.

catalogue number: K145
synonyms:
CAS: 99533-80-9
MW: 467.47 g/mol

References
Biochem Biophys Res Commun. 1990 Aug 31;171(1):148-54. PMID: 2393389
Biochem Biophys Res Commun. 1991 Nov 27;181(1):423-9. PMID: 1659814

Prices
  • 5 mg - 121 EUR
  • 25 mg - 484 EUR
  • 100 mg - 1452 EUR

KU0063794

KU0063794 is selective inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 10 nM. It displays no activity against PI3-kinase or 76 other kinases tested. It inhibits the activation of Akt, S6K and SGK, but not RSK. Treatment of cells suppresses their growth and induces G1 cell cycle arrest in vitro.

catalogue number: K046
synonyms: KU-0063794
CAS: 938440-64-3
MW: 465.54 g/mol

References
Biochem J. 2009 Jun 12;421(1):29-42. PMID: 19402821