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Prices
  • 5 mg - 64 EUR
  • 25 mg - 192 EUR
  • 100 mg - 576 EUR

H-89

H-89 is known as a selective and potent inhibitor of protein kinase A (PKA). However, H89 is able to inhibit at least eight additional protein kinases at 1 microM (PRKG1, PRKG2, PRKX, ROCK1, ROCK2, MSK1, MSK2, S6K1). IC50 values determined for the compound proved that three kinases (MSK1, S6K1 and ROCK2) were inhibited with a potency similar to or greater than that for PKA.

catalogue number: H142
synonyms:
CAS: 127243-85-0
MW: 519.28 g/mol

References
J Biol Chem. 1996 Oct 18;271(42):26157-64. PMID: 8824261
Biochem J. 2000 Oct 1;351(Pt 1):95-105. PMID: 10998351

Prices
  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

Hesperadin

Hesperadin is an inhibitor of the Aurora B protein kinase, against which it has an IC50 of 40 nM. Mammalian cells treated with Hesperadin enter anaphase with numerous monooriented chromosomes, many of which may have both sister kinetochores attached to one spindle pole (syntelic attachment). Hesperadin causes cells arrested by taxol or monastrol to enter anaphase within <1 h, whereas cells treated with nocodazole remain arrested for 3-5 h.

catalogue number: H037
synonyms:
CAS: 422513-13-1
MW: 516.65 g/mol

References
J Cell Biol. 2003 Apr 28;161(2):281-94. PMID: 12707311
Mol Cell. 2005 Apr 29;18(3):379-91. PMID: 15866179

Prices
  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

Hydroxyurea

Hydroxyurea is a drug that inhibits DNA synthesis by inhibiting ribonucleoside diphosphate reductase. The entire replicase complex, including ribonucleotide reductase, is inactivated and DNA synthesis is selectively inhibited, causing cell death in S phase and synchronizing the surviving cells. It is used in the clinic to treat myeloproliferative diseases, sickle-cell disease, AIDS, and psoriasis.

catalogue number: H083
synonyms: HU, Cytodrox, Hydrea, Biosupressin, Hydroxycarbamide
CAS: 127-07-1
MW: 76.05 g/mol

References
Semin Oncol. 1992 Jun;19(3 Suppl 9):1-10. PMID: 1641648