Alphabetical listing of all products

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Prices
  • 25 mg - 22 EUR
  • 100 mg - 65 EUR
  • 250 mg - 130 EUR

Fasudil

Fasudil is an inhibitor of Rho-associated kinase II with an IC50 value of 1.9 microM. This drug is marketed in Japan to treat cerebral vasospasm following surgery for subarachnoid hemorrhage and associated cerebral ischemic symptoms.

catalogue number: F137
synonyms: Eril, AT-877, HA-1077
CAS: 105628-07-7
MW: 327.83 g/mol (hydrochloride)

References
J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40. PMID: 3598899
Structure. 2006 Mar;14(3):589-600. PMID: 16531242

Prices
  • 25 mg - 52 EUR
  • 100 mg - 156 EUR
  • 250 mg - 312 EUR

FK-506

FK-506 is a potent immunosuppressant that is used after allogeneic organ transplantation to reduce the the risk of organ rejection. It disrupts signaling events mediated by calcineurin (Ca-dependent phosphatase) in T lymphocytes. Its mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with calcineurin and to interfere with its access to and dephosphorylation of various substrates. The knows substrates of calcineurin involved in induced immunosuppression include the nuclear factors of activated T cells (NFAT).

catalogue number: F138
synonyms: Fujimycin, Prograf, Tacrolimus
CAS: 104987-11-3
MW: 804.02 g/mol

References
Curr Med Chem. 2000 Jul;7(7):731-48. PMID: 10702636

Prices
  • 5 mg - 85 EUR
  • 25 mg - 340 EUR
  • 100 mg - 1020 EUR

Flavopiridol

Flavopiridol was initially identified as an inhibitor of cyclin-dependent kinases 1 and 2. However, its primary target is CDK9, the catalytic component of positive transcription elongation factor b (P-TEFb). It is currently being tested as an anticancer drug in numerous clinical trials.

catalogue number: F031
synonyms: Alvocidib, HMR-1275, L86-8275
CAS: 146426-40-6
MW: 401.84 g/mol

References
J Natl Cancer Inst. 1992 Nov 18;84(22):1736-40. PMID: 1279187
Biochem Biophys Res Commun. 1994 Jun 15;201(2):589-95. PMID: 8002990
Cell Cycle. 2004 Dec;3(12):1537-42. PMID: 15539947
EMBO J. 2008 Jul 9;27(13):1907-18. PMID: 18566585
Crystal structure of CDK9-cyclin T1 in complex with flavopiridol PDB: 3BLR

Prices
  • 25 mg - 28 EUR
  • 100 mg - 85 EUR
  • 250 mg - 170 EUR

Fluorouracil

Fluorouracil is a pyrimidine analog that noncompetitively inhibits thymidylate synthase. It is an antimetabolite that is used to treat cancer. In cells, it is transformed into various cytotoxic metabolites that become incorporated into DNA and RNA, ultimately inducing cell cycle arrest during S phase and apoptosis.

catalogue number: F124
synonyms: Adrucil, 5-FU, Carac, Efudex, Fluoroplex
CAS: 51-21-8
MW: 130.08 g/mol

References
Nat Rev Cancer. 2003 May;3(5):330-8. PMID: 12724731
Cell Mol Life Sci. 2009 Mar;66(5):788-99. PMID: 18979208

Prices
  • 5 mg - 80 EUR
  • 25 mg - 320 EUR
  • 100 mg - 960 EUR

Foretinib

Foretinib is a small-molecule inhibitor of the hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinases with single-digit nanomolar IC50 values. It also inhibits KIT, Flt-3, PDGFR-beta and Tie-2. Foretinib exerted cytotoxicity against a broad panel of cancer cell lines. It also reduced tumor cell migration, invasion, and tumor-induced angiogenesis.

catalogue number: F166
synonyms: EXEL-2880, XL880, GSK1363089
CAS: 849217-64-7
MW: 632.65 g/mol

References
Cancer Res. 2009 Oct 15;69(20):8009-16. PMID: 19808973
Cell Cycle. 2011 Dec 1;10(23):4138-48. PMID: 22101270
Structure of the kinase domain of c-Met/HGFR bound to foretinib PDB: 3LQ8

Prices
  • 5 mg - 43 EUR
  • 25 mg - 172 EUR
  • 100 mg - 516 EUR

Ftorafur

Ftorafur is a chemotherapeutic drug for the treatment of malignant tumors, particularly gastric, colorectal and breast cancers. It is is taken up by the cancer cells and hydrolyzed into 5-fluorouracil, which is the active cytostatic DNA anti-metabolite.

catalogue number: F032
synonyms: tegafur
CAS: 17902-23-7
MW: 200.17 g/mol

References
Neoplasma. 1972;19(4):341-5. PMID: 4262365
Cancer Res. 1975 May;35(5):1301-4. PMID: 1168096