Alphabetical listing of all products

A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

Prices
  • 5 mg - 140 EUR
  • 25 mg - 560 EUR
  • 100 mg - 1680 EUR

Cabozantinib

Cabozantinib is a small molecule kinase inhibitor of MET and VEGFR2, as well as a number of other receptor tyrosine kinases that have also been implicated in tumor pathobiology, including RET, KIT, AXL. Treatment with cabozantinib inhibited MET and VEGFR2 phosphorylation and led to significant reductions in cell invasion.

catalogue number: C090
synonyms: XL184
CAS: 849217-68-1
MW: 501.51 g/mol

References
Expert Opin Investig Drugs. 2011 Mar;20(3):407-413. PMID: 21314233
Mol Cancer Ther. 2011 Sep 16. PMID: 21926191

Prices
  • 5 mg - 74 EUR
  • 25 mg - 296 EUR
  • 100 mg - 888 EUR

CAL-101 (Idelalisib)

CAL-101 is a potent inhibitor of PI3 kinase with an IC50 of 65 nM for the p110d isoform. It blocks constitutive PI3K signaling, which disfavours Akt phosphorylation and promotes apoptosis in primary CLL cells ex vivo in a dose- and time-dependent fashion.

catalogue number: C020
synonyms: GS-1101
CAS: 870281-82-6
MW: 415.42 g/mol

References
Blood. 2010 Sep 23;116(12):2078-88. PMID: 20522708

Prices
  • 0.025 mg - 104 EUR
  • 0.100 mg - 312 EUR
  • 0.250 mg - 624 EUR

Calyculin A

Calyculin A is a potent inhibitor of protein phosphatases. It is highly specific for the PP-1 and PP-2 classes, against which it has Ki values of 0.1 nM. These serine/threonine protein phosphatases play essential roles in cellular signalling, metabolism, and cell cycle control.

catalogue number: C109
synonyms:
CAS: 101932-71-2
MW: 1009.19 g/mol

References
Drugs Exp Clin Res. 1988;14(12):723-8. PMID: 2472940
Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7. PMID: 2539153
Mar Drugs. 2010 Jan 21;8(1):122-72. PMID: 20161975

Prices
  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

CAN508

CAN508 was described as a selective inhibitor of transcriptional cyclin-dependent kinase 9. Its cellular effects include decreased phosphorylation of the C-terminal domain of RNA polymerase II, inhibition of mRNA synthesis, and induction of the tumor suppressor protein p53, all of which are consistent with inhibition of CDK9.

catalogue number: C021
synonyms: 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, CDK9 inhibitor II, 31b
CAS: 140651-18-9
MW: 218.2 g/mol

References
J Med Chem. 2006 Nov 2;49(22):6500-9. PMID: 17064068
Eur J Med Chem. 2011 Sep;46(9):4289-94. PMID: 21777997
ACS Chem Biol. 2012 PMID: 22292676
PDB Structure of its co-crystal with CDK2: 2CLX
PDB Structure of its co-crystal with CDK9/cyclin T: 3TN8

Prices
  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

Canertinib

Canertinib is an orally available irreversible inhibitor of receptor tyrosine kinases that targets EGFRs. It has IC50 values of 0.8, 19 and 7 nM for EGFR, HER-2 and ErbB-4, respectively. Canertinib was beány developed as an anticancer drug, but its development was discontinued.

catalogue number: C098
synonyms: CI-1033, PD-183805
CAS: 267243-28-7
MW: 485.94 g/mol

References
J Med Chem. 2000 Apr 6;43(7):1380-97. PMID: 10753475
IDrugs. 2004 Jan;7(1):58-63. PMID: 14730468

Prices
  • 25 mg - 43 EUR
  • 100 mg - 129 EUR
  • 250 mg - 258 EUR

Carboplatin

Carboplatin is a chemotherapy drug used against ovarian carcinoma as well as cancers of the lung, head, and neck. It binds to and cross-links DNA strands, causing DNA damage in the same way as cisplatin, although carboplatin is less reactive and exhibits slower DNA binding kinetics.

catalogue number: C117
synonyms: Paraplatin, Cycloplatin
CAS: 41575-94-4
MW: 371.25 g/mol

References
Dalton Trans. 2010 Sep 21;39(35):8113-27. PMID: 20593091

Prices
  • 5 mg - 140 EUR
  • 25 mg - 560 EUR
  • 100 mg - 1680 EUR

Cediranib

Cediranib is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of KDR tyrosine kinase. Concordant with this activity, it inhibits VEGF-stimulated proliferation and KDR phosphorylation in human umbilical vein endothelial cells with IC50 values of 0.4 and 0.5 nmol/L, respectively. In a fibroblast/endothelial cell co-culture model for vessel sprouting, Cediranib also reduced vessel area, length, and branching at subnanomolar concentrations.

catalogue number: C099
synonyms: AZD2171
CAS: 288383-20-0
MW: 450.51 g/mol

References
Cancer Res. 2005 May 15;65(10):4389-400. PMID: 15899831

Prices
  • 25 mg - 25 EUR
  • 100 mg - 75 EUR
  • 250 mg - 150 EUR

Celecoxib

Celecoxib is a potent inhibitor of cyclooxygenase-2, with IC50 value of 40 nM. It has been approved as a drug for rheumatoid arthritis, pain, menstrual cramps, and colonic polyps.

catalogue number: C022
synonyms: Celebrex, Celebra
CAS: 169590-42-5
MW: 381.37 g/mol

References
J Med Chem. 1997 Apr 25;40(9):1347-65. PMID: 9135032

Prices
  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

CHIR-99021

CHIR-99021 is a glycogen synthase kinase 3b (GSK3b) inhibitor with an IC50 value of 7 nM. It does not exhibit cross-reactivity against CDKs and is reported to have a 350-fold selectivity toward GSK3b. CHIR-99021 inhibits cellular proliferation with an IC50 value of about 10 microM.

catalogue number: C038
synonyms: CT99021
CAS: 252917-06-9
MW: 465.34 g/mol

References
Diabetes. 2003 Mar;52(3):588-95. PMID: 12606497

Prices
  • 5 mg - 53 EUR
  • 25 mg - 220 EUR
  • 100 mg - 660 EUR

CHIR-258

CHIR-258 is an orally bioavailable, inhibitor of VEGFR-2, FGFR-1, and PDGFRbeta, with IC50 values of <0.1 microM against these kinases. It is in phase III development for the treatment of renal cell carcinoma, and in phase II development as a treatment for advanced breast cancer, relapsed multiple myeloma and urothelial cancer.

catalogue number: C039
synonyms: Dovitinib, TKI258
CAS: 915769-50-5
MW: 500.53 g/mol

References
Blood. 2005 Apr 1;105(7):2941-8. PMID: 15598814
J Med Chem. 2009 Jan 22;52(2):278-92. PMID: 19113866

Prices
  • 25 mg - 22 EUR
  • 100 mg - 65 EUR
  • 250 mg - 130 EUR

Cisplatin

Cisplatin is an anticancer drug used to treat various types of cancers, including sarcomas, small cell lung cancer, ovarian cancer, lymphomas, and germ cell tumors. In cells, one of the chloride ligands is slowly displaced by water. This allows the platinum atom to bind to bases of DNA; it has a particularly high affinity for guanine. Cisplatin crosslinks DNA and thus interferes with its replication and cell division. This DNA damage triggers DNA repair mechanisms, which initiate apoptosis when repair proves impossible.

catalogue number: C118
synonyms: cisplatinum, cis-diamminedichloroplatinum(II), CDDP, Platinol, Platinol-AQ
CAS: 15663-27-1
MW: 300.05 g/mol

References
Anticancer Agents Med Chem. 2007 Jan;7(1):3-18. PMID: 17266502
Vet Comp Oncol. 2008 Mar;6(1):1-18. PMID: 19178659

Prices
  • 25 mg - 22 EUR
  • 100 mg - 65 EUR
  • 250 mg - 130 EUR

Colchicine

Colchicine is a natural product originally extracted from plants of the genus Colchicum. It inhibits microtubule polymerization and thus arrest the cell cycle during mitosis. Colchicine has been approved as a drug for the treatment of familial Mediterranean fever and acute gout flares, and for the prophylaxis of gout flares.

catalogue number: C119
synonyms: Colcrys
CAS: 64-86-8
MW: 399.44 g/mol

References
Med Res Rev. 2008 Jan;28(1):155-83. PMID: 17464966

Prices
  • 5 mg - 85 EUR
  • 25 mg - 340 EUR
  • 100 mg - 1020 EUR

Crizotinib

Crizotinib is an orally bioavailable, ATP-competitive, potent and selective dual inhibitor of the c-MET and ALK kinases. It has been particularly effective against anaplastic large cell lymphoma and non-small cell lung cancer (NSCLC) cell lines harboring ALK translocations that cause the expression of oncogenic ALK fusion proteins.

catalogue number: C023
synonyms: PF-02341066
CAS: 877399-52-5
MW: 450.34 g/mol

References
Curr Opin Investig Drugs. 2010 Dec;11(12):1477-90. PMID: 21154129
J Med Chem. 2011 Sep 22;54(18):6342-63. PMID: 21812414
Crystal structure of the PF-02341066/c-MET complex PDB: 2wgj
Crystal structure of the PF-02341066/ALK complex PDB: 2xp2

Prices
  • 5 mg - 98 EUR
  • 25 mg - 392 EUR
  • 100 mg - 1176 EUR

CVT313

CVT-313 is a potent and selective CDK2 inhibitor with an IC50 of 0.5 microM in vitro. Its IC50 against CDK4 is 215 microM while those against MAPK, PKA, and PKC are > 1.25 mM; it has no effect on other, non-related ATP-dependent serine/threonine kinases. In cells exposed to CVT-313, hyperphosphorylation of the retinoblastoma gene product was inhibited, and progression through the cell cycle was arrested at the G1/S boundary. CVT-313 also inhibits CDC5L.

catalogue number: C024
synonyms: -
CAS: 199986-75-9
MW: 400.47 g/mol

References
J Biol Chem. 1997 Nov 14;272(46):29207-11. PMID: 9360999
Cell Cycle. 2007 Dec 1;6(23):2982-9. PMID: 18156799
Cell Cycle. 2008 Jun 15;7(12):1795-803. PMID: 18583928

Prices
  • 5 mg - 74 EUR
  • 25 mg - 296 EUR
  • 100 mg - 888 EUR

CYC116

CYC116 is a small molecule inhibitor of aurora kinases A and B with K(i) values of 8.0 and 9.2 nM, respectively. Its anticancer effects were shown to emanate from cell death following mitotic failure and increased polyploidy due to cellular inhibition of the aurora kinases.

catalogue number: C025
synonyms: -
CAS: 693228-63-6
MW: 368.46 g/mol

References
J Med Chem. 2010 Jun 10;53(11):4367-78. PMID: 20462263

Prices
  • 25 mg - 59 EUR
  • 100 mg - 148 EUR
  • 250 mg - 296 EUR

Cyclophosphamide

Cyclophosphamide is a nitrogen mustard alkylating agent belonging to the oxazophorine class. It binds to N7 of guanine in DNA, on the imidazole ring, and forms both interstrand and intrastrand crosslinkages. Cyclophosphamide is used to treat various types of cancer and some autoimmune disorders.

catalogue number: C120
synonyms: Clafen, Endoxan, Cytoxan, Neosar, Procytox, Cytophosphane
CAS: 50-18-0
MW: 261.09 g/mol

References
Mutat Res. 1994 Dec;318(3):205-26. PMID: 7527485
Curr Pharm Des. 1999 Aug;5(8):555-60. PMID: 10469891

Prices
  • 5 mg - 97 EUR
  • 25 mg - 388 EUR
  • 100 mg - 1164 EUR

CYT387

CYT387 is a potent inhibitor of the JAK1 and JAK2 kinases (IC50=11 and 18 nM, respectively) that is significantly less active against other kinases, including JAK3 (IC50=155 nM). CYT387 caused growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines, while nonhematopoietic cell lines were unaffected. It is being developed to treat myeloproliferative neoplasms/disorders.

catalogue number: C101
synonyms: CYT 11387, Cyt-387
CAS: 1056634-68-4
MW: 414.47 g/mol

References
Leukemia. 2009 Aug;23(8):1441-5. PMID: 19295546
Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92. PMID: 19762238
Blood. 2010 Jun 24;115(25):5232-40. PMID: 20385788