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ZM447439

ZM447439 was the first inhibitor of the Aurora kinase family to be developed and characterized. It has IC50 values of 50 nM, 1 microM and 250 nM for Aurora kinases B, A and C, respectively. Its inhibition of these kinases interferes with the mitotic spindle integrity checkpoint and chromosome segregation.

catalogue number: Z082
synonyms:
CAS: 331771-20-1
MW: 513.59 g/mol

References
Mol Biol Cell. 2005 Mar;16(3):1305-18. PMID: 15616188
Biochem Pharmacol. 2010 Jan 15;79(2):122-9. PMID: 19686703