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  • 5 mg - 103 EUR
  • 25 mg - 412 EUR
  • 100 mg - 1236 EUR

YM155

YM155 has been identified as a small-molecule survivin suppresant. Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. In contrast, it had little effect on the expression of IAP- or Bcl-2 related proteins at concentrations below 100 nmol/L.

catalogue number: Y094
synonyms: Sepantronium Bromide
CAS: 781661-94-7
MW: 443.29 g/mol

References
Cancer Res. 2007 Sep 1;67(17):8014-21. PMID: 17804712