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Prices
  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

XAV-939

XAV939 selectively inhibits beta-catenin-mediated transcription. It stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex. XAV939 stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 with nanomolar IC50 values. Moreover, it exhibits 10- to 500-fold selectivity for the tankyrases over PARP1 and PARP2. Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway.

catalogue number: X081
synonyms: 2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol
CAS: 284028-89-3
MW: 312.31 g/mol

References
Nature. 2009 Oct 1;461(7264):614-20. PMID: 19759537
J Med Chem. 2010 Jul 22;53(14):5352-5. PMID: 20565110