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Wortmannin

Wortmannin is a fungal metabolite that has been shown to act as a selective inhibitor of phosphoinositide 3-kinases with IC50 values in low nanomolar range. It has been shown that wortmannin binds irreversibly in proximity to the substrate-binding site of PI3K. At higher concentrations, wortmannin inhibits also the ataxia telangiectasia gene (ATM)-related DNA-dependent protein kinase (DNA-PKcs).

catalogue number: W154
synonyms: KY12420
CAS: 19545-26-7
MW: 428.43 g/mol

References
Trends Biochem Sci. 1995 Aug;20(8):303-7. PMID: 7667888
Mol Cell Biol. 1996 Apr;16(4):1722-33. PMID: 8657148