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  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

WZ3146

WZ3146 is an irreversible inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M), which is detected in 50% of patients exhibiting resistance to gefitinib or erlotinib. WZ3146 is much less potent against wild-type EGFR kinase.

catalogue number: W092
synonyms:
CAS: 1214265-56-1
MW: 464.95 g/mol

References
Nature. 2009 Dec 24;462(7276):1070-4. PMID: 20033049