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  • 5 mg - 120 EUR
  • 25 mg - 480 EUR
  • 100 mg - 1440 EUR

Venetoclax

Venetoclax (ABT-199) is a selective small molecule inhibitor of Bcl-2. It mimics BH3-only proteins (the native ligands of Bcl-2 and apoptosis activators) and binds to the hydrophobic groove of Bcl-2, thereby repressing Bcl-2 activity and restoring apoptosis in cancer cells. This compound is orally available and has shown promising clinical activity in lymphoid malignancies such as chronic lymphocytic leukemia (Bcl-2-dependent).

catalogue number: V172
synonyms: ABT-199, ABT199, GDC0199
CAS: 1257044-40-8
MW: 868.44 g/mol

References
Nat Med. 2013 Feb;19(2):202-8. PMID: 23291630
Leuk Lymphoma. 2013 Aug;54(8):1823-5. PMID: 23614795