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Vinorelbine

Vinorelbine is a third-generation semi-synthetic vinca alkaloid that is related to vincristine but exhibits significantly lower toxicity towards neuronal tissue and greater cytotoxic activity than the older compounds in this class. It binds to tubulin and thereby inhibits microtubule assembly, arresting the cell cycle during mitosis. Vinorelbine has been approved for the treatment of non-small cell lung cancer and breast cancer.

catalogue number: V133
synonyms: Navelbine
CAS: 71486-22-1
MW: 778.93 g/mol

References
Cancer Invest. 1997;15(5):475-90. PMID: 9316630
Nat Rev Drug Discov. 2010 Oct;9(10):790-803. PMID: 20885410