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  • 25 mg - 85 EUR
  • 100 mg - 255 EUR
  • 250 mg - 510 EUR

VX-680

VX-680 is a highly potent and selective small-molecule inhibitor of Aurora kinases, with Ki values of 0.6, 18 and 4.6 nM against Aurora A, B and C, respectively. In addition, it has activity against BCR-ABL, including the T315I BCR-ABL mutant. VX-680 blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor types both in vitro and in vivo.

catalogue number: V080
synonyms: MK-0457, Tozasertib
CAS: 639089-54-6
MW: 464.59 g/mol

References
Nat Med. 2004 Mar;10(3):262-7. PMID: 14981513
Blood. 2007 Jan 15;109(2):500-2. PMID: 16990603
Cancer Lett. 2007 Jun 28;251(2):323-9. PMID: 17240048