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Prices
  • 25 mg - 103 EUR
  • 100 mg - 309 EUR
  • 250 mg - 618 EUR

Vandetanib

Vandetanib is a tyrosine kinase inhibitor that targets the VEGFR (IC50 = 40 nM) and EGFR (IC50 = 500 nM) receptors. It is a potent in vitro inhibitor of VEGFA-stimulated endothelial cell proliferation (IC50 = 60 nM) and has been demonstrated to selectively inhibit VEGF signaling in vivo in a growth factor-induced hypotension rat model.

catalogue number: V078
synonyms: Zactima, ZD6474
CAS: 443913-73-3
MW: 475.35 g/mol

References
J Med Chem. 2002 Mar 14;45(6):1300-12. PMID: 11881999
Cancer Res. 2002 Aug 15;62(16):4645-55. PMID: 12183421