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  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

U0126

U0126 was originally found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinases MEK with an IC50 of 70 nM for MEK1 and 60 nM for MEK2. Later, U0126 was reported to inhibit MKK1, and five-fold less potently also SAPK2a/p38, PRAK and PKB alpha.

catalogue number: U155
synonyms: -
CAS: 109511-58-2
MW: 380.49 g/mol

References
Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44. PMID: 9873633
Biochem J. 2000 Oct 1;351(Pt 1):95-105. PMID: 10998351