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  • 5 mg - 85 EUR
  • 25 mg - 340 EUR
  • 100 mg - 1020 EUR

Trametinib

Trametinib is a potent and selective allosteric inhibitor of the MEK1 and MEK2 kinases with strong antitumor activity. Trametinib inhibits prevents Raf-dependent MEK phosphorylation (S217 for MEK1), producing prolonged p-ERK1/2 inhibition. Cell growth inhibition is significant in most tumor lines with mutant BRAF or Ras. It undergoes trials in patients with metastatic BRAF-mutant melanoma.

catalogue number: T167
synonyms: GSK-1120212, JTP-74057
CAS: 871700-17-3
MW: 615.41 g/mol

References
Clin Cancer Res. 2011 Mar 1;17(5):989-1000. PMID: 21245089
J Clin Oncol. 2013 Feb 1;31(4):482-9. PMID: 23248257