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  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

Tyrphostin AG 1478

Tyrphostin AG 1478 is a specific inhibitor of the EGF-receptor tyrosine kinase (ERBB1) activity with an IC50 of about 3 nM in vitro. It is also very active against L858R and L861Q EGFR mutants. According to Invitrogen profiling, it displays moderate activity also against ERBB2 (HER2) and ERBB4 (HER4) receptors, LYNA and LYNB. AG1478 has very weak activity on PDGF and HER2-NEU kinases (IC50 values over 100 microM).

catalogue number: T151
synonyms: AG 1478
CAS: 175178-82-2
MW: 315.75 g/mol

References
Eur J Biochem. 1994 Nov 1;225(3):1047-53. PMID: 7525285
J Leukoc Biol. 1999 Jun;65(6):891-9. PMID: 10380915
Br J Haematol. 2000 Jun;109(4):823-8. PMID: 10929036