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Tyrphostin AG 490

Tyrphostin AG-490 potently inhibits the kinase activities of JAK2 and JAK3. Inhibition of Jak-2 activity by AG-490 selectively blocks leukaemic cell growth in vitro and in vivo by inducing programmed cell death (acute lymphoblastic leukaemia), with no deleterious effect on normal haematopoiesis. AG490 also suppresses cell proliferation and induces apoptosis in IL-6-dependent multiple myeloma cell lines. AG-490 inhibits JAK3-dependent activation of STAT5a/b and downstream signal transduction and cellular proliferation of antigen-activated human T cells.

catalogue number: T150
synonyms: Tyrphostin B42
CAS: 134036-52-5
MW: 294.30 g/mol

References
Nature. 1996 Feb 15;379(6566):645-8. PMID: 8628398