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Tivozanib

Tivozanib is an orally active, ATP-competitive inhibitor of VEGFR tyrosine kinase developed for the potential treatment of cancer. Tivozanib inhibits activation of VEGFR-1, VEGFR-2 and VEGFR-3 at picomolar concentrations. In preclinical studies, tivozanib produced a significant inhibition of tumor growth and angiogenesis in several different animal models.

catalogue number: T146
synonyms: AV-951, KRN-951
CAS: 475108-18-0
MW: 454.86 g/mol

References
IDrugs. 2010 Sep;13(9):636-45. PMID: 20799147
Clin Cancer Res. 2011 Nov 15;1 PMID: 21976547