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  • 5 mg - 238 EUR
  • 25 mg - 952 EUR
  • 100 mg - 2856 EUR

Tipifarnib

Tipifarnib is a potent and selective inhibitor of farnesyl protein transferase that has significant antitumor effects in vivo. Tipifarnib competitively inhibits the farnesylation of lamin B and K-RasB peptide substrates, with IC50 values of 0.86 nM and 7.9 nM, respectively. Tumor cell lines bearing H-ras or N-ras mutations were among the most sensitive of the cell lines tested, with responses observed at nanomolar concentrations of tipifarnib. The activity of this compound in the myeloid malignancies of myelodysplastic syndrome, myelofibrosis and elderly/high-risk acute myeloid leukemia is of particular interest.

catalogue number: T108
synonyms: Zarnestra, R115777
CAS: 192185-72-1
MW: 489.4 g/mol

References
Cancer Res. 2001 Jan 1;61(1):131-7. PMID: 11196150
Expert Rev Anticancer Ther. 2006 Mar;6(3):313-9. PMID: 16503848