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  • 5 mg - 160 EUR
  • 25 mg - 640 EUR
  • 100 mg - 1920 EUR

SCH900776 (MK-8776)

SCH900776 is a potent and selective inhibitor of check-point kinase 1 (CHK1) with IC50 value of 3 nM. Sensitivity of CHK2 is 500 fold lower (IC50 value of 1500 nM). Consistently with its kinase inhibitory activity, SCH900776 abrogates cell-cycle arrest induced by SN38. It interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double strand DNA breaks and cell death in tumor cells.

catalogue number: S165
synonyms: SCH 900776, SCH-900776, MK-8776
CAS: 891494-63-6
MW: 376.25 g/mol

References
Mol Cancer Ther. 2011 Apr;10(4):591-602. PMID: 21321066
Mol Cancer Ther. 2012 Feb;11(2):427-38. PMID: 22203733