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SB203580

SB203580 is an inhibitor of the p38 mitogen-activated protein (MAP) kinases, selectively inhibiting SAPK2a and SAPK2b (p38 beta2) with I50 values of 50 nM and 500 nM, respectively. It was originally prepared as inflammatory cytokine synthesis inhibitor.

catalogue number: S148
synonyms: -
CAS: 152121-47-6
MW: 377.43 g/mol

References
Pharmacol Ther. 1999 May-Jun;82(2-3):389-97. PMID: 10454214
Biochem J. 2000 Oct 1;351(Pt 1):95-105. PMID: 10998351
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. PMID: 18077363