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  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

SB202190

SB202190 is an inhibitor of the p38 mitogen-activated protein (MAP) kinases that regulate signal transduction in response to environmental stress. It inhibits SAPK2a and SAPK2b (p38 beta2) with I50 values of 50 nM and 100 nM, respectively. It also targets BRAF and cRAF kinases. In cells, SB202190 induces cell death, with typical apoptotic features such as nucleus condensation, caspase activation and intranucleosomal DNA fragmentation.

catalogue number: S147
synonyms: -
CAS: 152121-30-7
MW: 331.34 g/mol

References
Chem Biol. 1997 Jun;4(6):423-31. PMID: 9224565
J Biol Chem. 1998 Jun 26;273(26):16415-20. PMID: 9632706
Biochem J. 2000 Oct 1;351(Pt 1):95-105. PMID: 10998351
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. PMID: 18077363