Alphabetical listing of all products

A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

Prices
  • 5 mg - 41 EUR
  • 25 mg - 164 EUR
  • 100 mg - 492 EUR

(S)-roscovitine

Roscovitine is a highly efficient and selective inhibitor of certain cyclin-dependent kinases, including CDK2, CDK5, CDK7 and CDK9. In addition to its anticancer activities (and in contrast to the R isomer), S-roscovitine is being studied as a potential neuroprotectant for stroke because it can cross the blood brain barrier. In the brain, its inhibition of CDK5 blocks hypoxia-induced apoptosis in neurons.

catalogue number: R074
synonyms:
CAS: 186692-45-5
MW: 354.45 g/mol

References
J Med Chem. 1997 Feb 14;40(4):408-12. PMID: 9046330
Acc Chem Res. 2003 Jun;36(6):417-25. PMID: 15648953
Nat Rev Neurol. 2010 Oct;6(10):527. PMID: 20949660