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RGB-286638

RGB-286638 is a cyclin-dependent kinase inhibitor with IC50 values of 1, 2, 3 and 44 nM for CDK9, CDK1, CDK2, and CDK4, respectively. It has been shown to inhibit cell cycle progression in cancer cells by targeting CDKs, and was also found to induce apoptosis. In a range of pre-clinical models of solid and hematological tumors, RGB-286638 treatment resulted in tumor regression and increased survival.

catalogue number: R069
synonyms:
CAS: 784210-88-4
MW: 545.65 g/mol

References
J Pharm Biomed Anal. 2009 Dec 5;50(5):977-82. PMID: 19628352