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R547

R547 is a CDK inhibitor (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines. Its growth-inhibitory activity is characterized by cell cycle blockage in the G(1) and G(2) phases, reduced phosphorylation of the cellular retinoblastoma protein, and induction of apoptosis.

catalogue number: R068
synonyms:
CAS: 741713-40-6
MW: 441.45 g/mol

References
J Med Chem. 2006 Nov 2;49(22):6549-60. PMID: 17121911
Mol Cancer Ther. 2006 Nov;5(11):2644-58. PMID: 17064073