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  • 5 mg - 98 EUR
  • 25 mg - 164 EUR
  • 100 mg - 492 EUR

Purvalanol A

Purvalanol A is cyclin-dependent kinase inhibitor with IC50 values of 4, 70, 850 and 75 nM for CDK1, CDK2, CDK4 and CDK5, respectively. It is a strong inducer of cell cycle arrest during the G2-M phase, and a potent suppressor of the anchorage-independent growth of c-Src-transformed cells. It also effectively suppressed the growth of human colon cancer HT29 and SW480 cells that express oncogenic Src.

catalogue number: P066
synonyms:
CAS: 212844-53-6
MW: 388.9 g/mol

References
Science. 1998 Jul 24;281(5376):533-8. PMID: 9677190
Int J Cancer. 2002 Feb 20;97(6):761-9. PMID: 11857351
Genes Cells. 2010 Oct;15(10):1051-62. PMID: 20825494