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  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

PHA-680632

PHA-680632 is a highly selective Aurora kinase inhibitor and an anticancer drug candidate. Its IC50 values against Aurora kinases A, B and C are 27, 135 and 120 nM, respectively, and it potently inhibits Histone H3 phosphorylation at Ser10. PHA-680632 is active against a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models.

catalogue number: P065
synonyms:
CAS: 398493-79-3
MW: 501.62 g/mol

References
Clin Cancer Res. 2006 Jul 1;12(13):4080-9. PMID: 16818708