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Prices
  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

Pazopanib

Pazopanib is a potent inhibitor of all three VEGFR receptors, with IC50 values of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively. It also displays significant activity against closely related kinases (notably, PDGFRb, c-Kit, FGF-R1, c-fms) with IC50 values in the submicromolar range. Pazopanib inhibits tumor vacsularization (angiogenesis) and thus blocks tumor growth.

catalogue number: P062
synonyms: GW786034, Armala, Votrient
CAS: 444731-52-6
MW: 473.98 g/mol

References
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19478-83. PMID: 17164332
J Med Chem. 2008 Aug 14;51(15):4632-40. PMID: 18620382
Drugs. 2011 Mar 5;71(4):443-54. PMID: 21395357