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  • 5 mg - 52 EUR
  • 25 mg - 208 EUR
  • 100 mg - 624 EUR

Paclitaxel

Paclitaxel stabilizes microtubules and interferes with their dynamics during cell division. Paclitaxel-treated cells exhibit defects in mitotic spindle assembly, chromosome segregation, and cell division. This blocks the progression of mitosis, and prolonged activation of the mitotic checkpoint triggers apoptosis. Paclitaxel is approved for the treatment of ovarian, breast and lung cancers and Kaposi's sarcoma.

catalogue number: P061
synonyms: Taxol
CAS: 33069-62-4
MW: 853.91 g/mol

References
Pharmacol Ther. 1984;25(1):83-125. PMID: 6149569
Med Res Rev. 1998 Sep;18(5):315-31. PMID: 9735872