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Olomoucine II

Olomoucine II is potent inhibitor of several cyclin-dependent kinases (CDKs). It is an ATP-competitor that binds to the active site of CDK2, as demonstrated by the analysis of co-crystal structures. In addition to its inhibition of the main cell cycle-regulating kinase CDK2, olomoucine II also binds to CDK7 and CDK9, which play important roles in regulating RNA transcription. It has been shown to have in vitro anticancer activity against a panel of tumor cell lines.

catalogue number: O059
synonyms:
CAS: 500735-47-7
MW: 370.45 g/mol

References
Bioorg Med Chem Lett. 2002 Nov 18;12(22):3283-6. PMID: 12392733
Cell Mol Life Sci. 2005 Aug;62(15):1763-71. PMID: 16003486
Crystal structure of human CDK2 in complex with olomoucine II PDB: 2A0C