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  • 5 mg - 41 EUR
  • 25 mg - 164 EUR
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Olomoucine

Olomoucine was one of the first selective inhibitors of cyclin-dependent kinases (CDKs) to be discovered. It competes with ATP for binding to the kinase active site, as demonstrated by the structure of a co-crystal with human CDK2. It was discovered by screening a library of 2,6,9-trisubstituted purines. Studies on olomoucine analogues resulted in the identification of the much more potent inhibitor roscovitine.

catalogue number: O058
synonyms: 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine
CAS: 101622-51-9
MW: 298.34 g/mol

References
Eur J Biochem. 1994 Sep 1;224(2):771-86. PMID: 7925396
Biol Cell. 1995;83(2-3):105-20. PMID: 7549905
Proteins. 1995 Aug;22(4):378-91. PMID: 7479711
Crystal structure of human CDK2 in complex with olomoucine PDB: 1W0X