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Nutlin-3

Nutlin-3 is an inhibitor of protein-protein interactions between the p53 tumour suppressor and the protooncogene MDM-2. Nutlin-3 binds to MDM-2 in the p53-binding pocket with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutations in p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice.

catalogue number: N095
synonyms:
CAS: 548472-68-0
MW: 581.5 g/mol

References
Science. 2004 Feb 6;303(5659):844-8. PMID: 14704432