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  • 25 mg - 103 EUR
  • 100 mg - 309 EUR
  • 250 mg - 618 EUR

Nilotinib

Nilotinib is a potent inhibitor of the BCR/Abl protein kinase that was developed as a drug against Philadelphia chromosome positive chronic myeloid and acute lymphoblastic leukemias. Nilotinib is approximately 20 times more potent than imatinib, and this translates into improved inhibitory activity against most of the common BCR-ABL mutations.

catalogue number: N056
synonyms: AMN-107, Tasigna
CAS: 641571-10-0
MW: 529.52 g/mol

References
Cancer Cell. 2005 Feb;7(2):117-9. PMID: 15710324
Cancer Cell. 2005 Feb;7(2):129-41. PMID: 15710326
Br J Cancer. 2006 Jun 19;94(12):1765-9. PMID: 16721371
Crystal structure of ABL in complex with nilotinib PDB: 3CS9