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NG38

NG38 is an estrogen sulfotransferase (EST) inhibitor identified from a trisubstituted purine library. It has an IC50 of 500 nM against the purified enzyme. EST catalyzes the transfer of a sulfuryl group to estrogens in the cytosol, solubilizing them to maintain hormone homeostasis. Unusually high levels of estrogen sulfate are found in breast tumor cells and EST is therefore considered to be a potential drug target. Unusually high levels of estrogen sulfate are found in breast tumor cells and EST is therefore considered as a possible drug target.

catalogue number: N055
synonyms:
CAS: 244030-38-4
MW: 394.51 g/mol

References
J Med Chem. 2001 Aug 16;44(17):2683-6. PMID: 11495578