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  • 5 mg - 176 EUR
  • 25 mg - 704 EUR
  • 100 mg - 2112 EUR

Neratinib

Neratinib is an orally available tyrosine kinase inhibitor with IC50 values of 59 nM and 92 nM for HER2 and EGFR, respectively. In contrast to other tyrosine kinase inhibitors that are ATP-competitors, Neratinib binds to the HER2 receptor irreversibly, forming a covalent bond with a cysteine residue in the ATP-binding pocket. Treatment of cells with neratinib inhibits mitogenic signal transduction events and induces arrest during the G1/S phase transition of the cell cycle.

catalogue number: N054
synonyms: HKI-272
CAS: 698387-09-6
MW: 557.04 g/mol

References
Cancer Res. 2004 Jun 1;64(11):3958-65. PMID: 15173008
J Med Chem. 2005 Feb 24;48(4):1107-31. PMID: 15715478