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Prices
  • 25 mg - 172 EUR
  • 100 mg - 516 EUR
  • 250 mg - 1032 EUR

Masitinib

Masitinib is a tyrosine kinase inhibitor that targets KIT with an IC50 value of 200 nM. Masitinib also potently inhibited recombinant PDGFR and the intracellular kinase Lyn. In contrast, it was a weak inhibitor of ABL and c-Fms and was inactive against a variety of other tyrosine and serine/threonine kinases. Kinetic analyses suggest that its mode of binding is different from that of imatinib; it also proved to be a stronger inhibitor of degranulation, cytokine production, and bone marrow mast cell migration than imatinib. It has been approved as a veterinary medicine for the treatment of mast cell tumors in dogs.

catalogue number: M102
synonyms: AB1010, Masivet, Masatinib
CAS: 790299-79-5
MW: 498.64 g/mol

References
PLoS One. 2009 Sep 30;4(9):e7258. PMID: 19789626