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  • 5 mg - 43 EUR
  • 25 mg - 172 EUR
  • 100 mg - 516 EUR

2-Methoxyestradiol

2-Methoxyestradiol is a steroid-like compound with very weak affinity for estrogen receptors. 2-ME2 prevents the formation of new blood vessels that tumors need for their growth (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers. 2-ME2 binds to microtubules and triggers their disruption, leading to an apoptotic cell death. Preclinical models also suggest that it could also be effective against inflammatory diseases such as rheumatoid arthritis.

catalogue number: M003
synonyms: 2-ME2, 2ME2
CAS: 362-07-2
MW: 302.41 g/mol

References
Steroids. 2010 Oct;75(10):625-31. PMID: 20214913
Mol Pharm. 2010 Dec 6;7(6):2030-9. PMID: 20831190