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  • 25 mg - 34 EUR
  • 100 mg - 103 EUR
  • 250 mg - 206 EUR

Irinotecan

Irinotecan is a semisynthetic analogue of the natural alkaloid camptothecin. Hydrolysis results in its conversion to SN-38, an inhibitor of topoisomerase I. Inhibition of topoisomerase I by the active metabolite SN-38 prevents DNA replication and transcription. Irinotecan is a second line chemotherapy for advanced colorectal cancer that is used if first-line treatments with oxaliplatin and 5-fluorouracil fail.

catalogue number: I125
synonyms: CPT-11, Camptosar, Campto
CAS: 97682-44-5
MW: 586.68 g/mol

References
World J Gastroenterol. 2009 Aug 7;15(29):3597-602. PMID: 19653336