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  • 5 mg - 64 EUR
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H-89

H-89 is known as a selective and potent inhibitor of protein kinase A (PKA). However, H89 is able to inhibit at least eight additional protein kinases at 1 microM (PRKG1, PRKG2, PRKX, ROCK1, ROCK2, MSK1, MSK2, S6K1). IC50 values determined for the compound proved that three kinases (MSK1, S6K1 and ROCK2) were inhibited with a potency similar to or greater than that for PKA.

catalogue number: H142
synonyms:
CAS: 127243-85-0
MW: 519.28 g/mol

References
J Biol Chem. 1996 Oct 18;271(42):26157-64. PMID: 8824261
Biochem J. 2000 Oct 1;351(Pt 1):95-105. PMID: 10998351