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Hesperadin

Hesperadin is an inhibitor of the Aurora B protein kinase, against which it has an IC50 of 40 nM. Mammalian cells treated with Hesperadin enter anaphase with numerous monooriented chromosomes, many of which may have both sister kinetochores attached to one spindle pole (syntelic attachment). Hesperadin causes cells arrested by taxol or monastrol to enter anaphase within <1 h, whereas cells treated with nocodazole remain arrested for 3-5 h.

catalogue number: H037
synonyms:
CAS: 422513-13-1
MW: 516.65 g/mol

References
J Cell Biol. 2003 Apr 28;161(2):281-94. PMID: 12707311
Mol Cell. 2005 Apr 29;18(3):379-91. PMID: 15866179