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  • 5 mg - 305 EUR
  • 25 mg - 1220 EUR
  • 100 mg - on request

GSK1210151A

GSK1210151A is an inhibitor of BET family of acetyl-lysine recognizing, chromatin proteins. The mode of action of GSK1210151A is based on the inhibition of transcription through the displacement of BRD3/4, PAFc and SEC components from chromatin. GSK1210151A has profound efficacy against human and murine mixed lineage leukaemia (MLL-fusions) and has also a potential for the treatment of inflammations.

catalogue number: G164
synonyms: I-BET151
CAS: 1300031-49-5
MW: 415.44 g/mol

References
Nature. 2011 Oct 2;478(7370):529-33. PMID: 21964340
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. PMID: 22437115
PDB Structure of its co-crystal with human BRD4: PDB: 3ZYU