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  • 25 mg - 72 EUR
  • 100 mg - 216 EUR
  • 250 mg - 432 EUR

GW2580

GW2580 is an orally bioavailable inhibitor of cFMS receptor kinase. It completely inhibited human cFMS kinase in vitro at 0.06 microM. GW2580 selectively inhibited cFMS kinase compared with 186 other kinases in vitro and completely inhibited CSF-1-induced growth of rat monocytes, with an IC50 value of 0.2 microM. GW2580 at 1 microM completely inhibited CSF-1-induced growth of mouse myeloid cells and human monocytes and completely inhibited bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone.

catalogue number: G141
synonyms: -
CAS: 870483-87-7
MW: 366.41 g/mol

References
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. PMID: 16249345
J Pharmacol Exp Ther. 2008 Jul;326(1):41-50. PMID: 18434589