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Geldanamycin

Geldanamycin is a benzoquinone ansamycin antibiotic that binds to and inhibits the functioning of heat shock protein 90 (Hsp90). Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate. This has stimulated the development of geldanamycin analogues, and especially analogues bearing modifications at the 17 position such as 17-AAG and 17-DMAG.

catalogue number: G035
synonyms:
CAS: 30562-34-6
MW: 560.64 g/mol

References
Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8324-8. PMID: 8078881
Cancer Lett. 2010 Apr 1;290(1):24-35. PMID: 19850405