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  • 5 mg - 80 EUR
  • 25 mg - 320 EUR
  • 100 mg - 960 EUR

Foretinib

Foretinib is a small-molecule inhibitor of the hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinases with single-digit nanomolar IC50 values. It also inhibits KIT, Flt-3, PDGFR-beta and Tie-2. Foretinib exerted cytotoxicity against a broad panel of cancer cell lines. It also reduced tumor cell migration, invasion, and tumor-induced angiogenesis.

catalogue number: F166
synonyms: EXEL-2880, XL880, GSK1363089
CAS: 849217-64-7
MW: 632.65 g/mol

References
Cancer Res. 2009 Oct 15;69(20):8009-16. PMID: 19808973
Cell Cycle. 2011 Dec 1;10(23):4138-48. PMID: 22101270
Structure of the kinase domain of c-Met/HGFR bound to foretinib PDB: 3LQ8