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Flavopiridol

Flavopiridol was initially identified as an inhibitor of cyclin-dependent kinases 1 and 2. However, its primary target is CDK9, the catalytic component of positive transcription elongation factor b (P-TEFb). It is currently being tested as an anticancer drug in numerous clinical trials.

catalogue number: F031
synonyms: Alvocidib, HMR-1275, L86-8275
CAS: 146426-40-6
MW: 401.84 g/mol

References
J Natl Cancer Inst. 1992 Nov 18;84(22):1736-40. PMID: 1279187
Biochem Biophys Res Commun. 1994 Jun 15;201(2):589-95. PMID: 8002990
Cell Cycle. 2004 Dec;3(12):1537-42. PMID: 15539947
EMBO J. 2008 Jul 9;27(13):1907-18. PMID: 18566585
Crystal structure of CDK9-cyclin T1 in complex with flavopiridol PDB: 3BLR