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  • 5 mg - 194 EUR
  • 25 mg - 776 EUR
  • 100 mg - 2328 EUR

Estybon

Estybon is a non-ATP-competitive inhibitor of protein kinase Plk1 with an IC50 of 9 nM. It inhibits mitotic progression and induces apoptosis in most cancer cell lines. It is in phase III trials for myelodysplastic syndromes associated with aberrant expression of cyclin D proteins.

catalogue number: E030
synonyms: ON-01910, rigosertib
CAS: 1225497-78-8
MW: 473.47 g/mol

References
Cancer Res. 2011 Jul 15;71(14):4968-76. PMID: 21646468
J Med Chem. 2011 Sep 22;54(18):6254-76. PMID: 21812421