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  • 5 mg - 130 EUR
  • 25 mg - 520 EUR
  • 100 mg - on request

Dinacliclib

Dinacliclib inhibits CDK2, CDK5, CDK1, and CDK9 activity in vitro with IC50 values of 1, 1, 3, and 4 nmol/L, respectively. In cell-based assays, it completely suppressed pRB phosphorylation, blocked cellular replication, and induced apoptosis. Dinacliclib induced regression of established solid tumors in a range of mouse models following intermittent scheduling of doses below the maximally tolerated level.

catalogue number: D071
synonyms: SCH-727965, MK-7965
CAS: 779353-01-4
MW: 396.49 g/mol

References
Mol Cancer Ther. 2010 Aug;9(8):2344-53. PMID: 20663931
Mol Cancer Ther. 2011 Apr;10(4):591-602. PMID: 21321066